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KMID : 1134120080110030116
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Journal of Breast Cancer
2008 Volume.11 No. 3 p.116 ~ p.124
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Correlation between the Her-2/neu Status as Determined by Immunohistochemical Analysis and the Serum Her-2/neu Concentration as Determined by the Use of ADVIA Cencaur® Automated Immunoassay in Breast Cancer Patients
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Lee Jung-Sun
Min Won-Ki
Park Eun-Hwa
Lim Woo-Sung
Choi Sung-Rym
Son Byung-Ho
Kim Sung-Bae
Ahn Jin-Hee
Ahn Sei-Hyun
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Abstract
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Purpose: Serum Her-2/neu is extracted from the extracelluar domain of the Her-2/neu tyrosine kinase to serum. We evaluated the correlation between the Her-2/neu status as determined by immunohistochemical analysis (IHC) and the serum Her-2/neu concentration in a population of Korean women with breast cancer.
Methods: Serum Her-2/neu levels were examined from 254 female patients with primary breast cancer and 38 patients with metastatic breast cancer. Serum Her-2/neu levels were measured by the use of a chemiluminescence immunoassay (ADVIA centaur? system) during the preoperative period. The level of Her-2/neu in all of the breast cancer tissue samples was determined by IHC, and samples with an IHC grade +2 were subject to fluorescence in situ (FISH). When tissue samples exhibited IHC grade +3 or showed amplification of Her-2/neu as determined by FISH analysis, Her-2/neu was considered overexpressed. The cut-off value for serum Her- 2/neu level was 10.2 ng/mL.
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KEYWORD
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Her-2/neu
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